|First things first - it looks like the focus is "wrong" somehow, as the building in the middle of the shot looks oddly soft, as do the bridges. Maybe a bit more USM/sharpening would help? This is probably the biggest detractor from the shot.
Secondly, framing/composition - there's a huge amount of dead space in the foreground, which could easily have been cropped out. In fact, cropping a bit off the sky as well would have made this into a good semi-pano shot, as the bridges lead the eye nicely into the centre.
Finally, the colours - it's a very blue shot, so IMO you should either go with a blue duotone, or seriously boost the saturation of the other colours. Alternatively, this shot may work better in B&W, since the water gives a good contrast texture.
Hope that all helps!