Very nice to my eyes. She has a wonderful smile that extends to her eyes . . . or perhaps her eyes smile first and the warmth then extends to her mouth. I very much like the background - the radiating lines and circles/bokeh extend the friendship in a sort of visual metaphor. Had you not told us, I'd have thought you added the noise . . . it's that perfect :)
My graphic-designer instinct is to say this would work well for a print ad with the space on the left for type.
My camera gives me noise like that at ISO 400, and printed photos (as in magazines) are built of nearly-visible dots of ink ... I find the quality of the composition and overall "feel" make the noise largely irrelevant or perhaps even an additional "feature".
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