I have the 467 and I really like it. The bottom padded section works well, and the padding will come out if you want (I sometimes lift it out and into a canvas messenger bag--instant camera bag!
Between the upper and lower sections, I have, on occasion, been able to squeeze two bodies with lenses, plus a third lens. But a single body, 3 lenses, and a speedlight should be no problem at all. The zipper pockets on the back work great for batteries and such.
I use the laptop section to carry straps, folded reflectors, battery chargers (if on travel) so it is a very flexible bag.
I used it to take a d80 w/battery grip with 18-200mm zoom, a canon g10, a gps, a portable dvd player and noise reduction headphones, batteries, a kindle, and a laptop on a trip to the UK.
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