I am no expert, and haven't ever shot in a nightclub. That said, I did a concert once, and expect that the lighting would be similar. I shot with my 50mm at F/1.8, ISO 400, and a decent shutter speed (don't remember exactly what) Used full Manual, and while the camera thought it was underexposing, it came out okay.
Here's an example of what the lighting can look like:
Spot lights can be really cool, especially colored ones!
You should of course try some with the flash, but I would use to to highlight people at the club, and try to let the natural lighting dominate as much as possible. Shots that are wholly flash-lit would not capture the atmosphere as well, IMO.
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