I'm having trouble understanding all of the question...I'm assuming...you're shooting with the D300, with the camera set to sRGB, which I'm assuming is Nikon sRGB, right? Then, you're using some software (Photoshop? CaptureNX?) to look at the files and convert to sRGB IEC 1966-2.1, which causes a nasty color shift.
Here's what I know....
sRGB IEC 1966-2.1 is the "official" sRGB. However, Nikon sRGB *shouldn't* be all that different from the standard version. If you're "converting" from one sRGB profile to another (as opposed to "applying" the profile), you shouldn't really see any kind of color shift. At least not much of one.
That said, I've also been having some wacky color problems since I got my D300, which I haven't quite figured out yet. Converting from any working profile to sRGB using "save for web" in Photoshop amps up the color to shocking levels, even when I'm shooting raw. No idea why this is happening. Since it's supposed to rain buckets here this weekend, I was planning on sitting down and figuring it out tomorrow.
As a short term fix, I've been converting from my working profile to my calibrated monitor profile, then removing the profile before uploading to the web. If your monitor is calibrated correctly, this should do what you need.
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